I use Photoshop to adjust or modify paper-drawings. Sometimes I vectorize black & white scribbles in Illustrator. There is always a bit of digital process involved. But I have never really drawn anything from scratch in graphic programs. It feels saver, more natural and closer to my ideas using pen and paper. There a certain restrictions (or call them disadvantages) that I like, for example that the sheet has a fixed height and width which you can´t change and the fear to fuck it up without beeing able to click your way back (no clean version control). I also like the soft scratching sound when the pen rolls over the paper and to tear a failure into pieces. It´s hard to do that with a graphic tablet.